- Title
- A Persistent Neutrophil-Associated Iimmune Signature Characterizes Post-COVID-19 Pulmonary Sequelae
- Creator
- George, Peter M.; Reed, Anna; Man, William D-C.; Kaul, Sundeep; Singh, Suveer; Lamb, Georgia; Faizi, Fatima K.; Schuliga, Michael; Read, Jane; Burgoyne, Thomas; Pinto, Andreia L.; Micallef, Jake; Desai, Sujal R.; Bauwens, Emilie; Candiracci, J; Bougoussa, M; Herzog, M; Raman, L; Ahmetaj-Shala, B; Turville, S; Aggarwal, A; Farne, HA; Dalla Pria, A; Devaraj, Anand; Aswani, AD; Patella, F; Borek, WE; Mitchell, JA; Bartlett, Nathan W.; Dokal, A; Xu, X-N; Kelleher, P; Shah, A; Singanayagam, A; Faiez, Tasnim Shahridan; Laverty, Sarah; Kanwal, Amama; Esneau, Camille; Liu, Michael K. C.; Kamal, Faisal
- Relation
- Science Translational Medicine Vol. 14, Issue 671, no. eabo5795
- Publisher Link
- http://dx.doi.org/10.1126/scitranslmed.abo5795
- Publisher
- American Association for the Advancement of Science (AAAS)
- Resource Type
- journal article
- Date
- 2022
- Description
- Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.
- Subject
- COVID-19; lung; functional changes; long-term complications; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1479977
- Identifier
- uon:50423
- Identifier
- ISSN:1946-6234
- Rights
- This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. This license does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using this material.
- Language
- eng
- Full Text
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